Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma
| Autor: | Zihe Dong BS, Zhipeng Liao BS, Yonglin He BS, Chengye Wu BS, Zixiang Meng BS, Baolong Qin BS, Ge Xu BS, Zeyang Li BS, Tianxin Sun BS, Yuyan Wen BS, Guangjie Li PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Technology in Cancer Research & Treatment, Vol 21 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1533-0338 15330338 |
| DOI: | 10.1177/15330338221117386 |
| Popis: | Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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