Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate
| Autor: | Caramelli Bruno, Bernoche Claudia Y.S.M. de, Sartori Ana M. C., Sposito Andrei C., Santos Raul D., Monachini Maristela C., Strabelli Tania, Uip Davi |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 5, Iss 6, Pp 332-338 (2001) |
| Druh dokumentu: | article |
| ISSN: | 1413-8670 1678-4391 |
| Popis: | Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p |
| Databáze: | Directory of Open Access Journals |
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