Effectiveness of antenatal intermittent preventive treatment for malaria with sulphadoxine-pyrimethamine on peripartum outcomes
| Autor: | Isaac Okezie Godwin, Ifeoma Mercy Ekejindu, George Uchenna Eleje, Dorothy Amauche Ezeagwuna, Chigozie Geoffrey Okafor, Arinze Anthony Onwuegbuna, Osita Samuel Umeononihu, Prisca Obiageli Godwin, Onyecherelam Monday Ogelle, Joseph Ifeanyichukwu Ikechebelu |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Infectious Disease, Vol 9 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2049-937X 20499361 |
| DOI: | 10.1177/20499361221122620 |
| Popis: | Background: Following the World Health Organization (WHO) recommendations for 4-weekly antenatal intermittent preventive treatment of malaria in pregnancy using sulphadoxine-pyrimethamine (IPTp-SP), there is a need to evaluate the drug performance in order to determine their effectiveness as tools in malaria control policy. Objectives: To determine prevalence of cord blood malaria, compliance gap and adverse pregnancy outcomes (anaemia, preterm delivery, spontaneous abortion, intra-uterine foetal death and low birth weight) among antenatal IPTp-SP users compared with non-users. Methods: A cross-sectional analytical study was conducted among consenting 390 participants who were administered a questionnaire, and paired blood samples were collected from the venous blood of participants and neonatal cord immediately after delivery. The participants were categorised as IPTp-SP users and non-users. Adverse pregnancy outcomes were assessed. Neonatal birth weights were also measured within 1 h after delivery. Malaria parasitaemia and anaemia were analysed using standard parasitological and haematological methods of examination. Data were analysed using SPSS version 25 for Windows and p -value of |
| Databáze: | Directory of Open Access Journals |
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