Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions

Autor:	Faranak Ghaderi, Mahboob Nemati, Mohammad Reza Siahi-Shadbad, Hadi Valizadeh, Farnaz Monajjemzadeh
Jazyk:	angličtina
Předmět:	Hydrochlorothiazide/lactose/Maillard reaction Hydrochlorothiazide/lactose/interaction/kinetic parameters High Performance Liquid Chromatography (HPLC)/kinetic parameters study. Pharmacy and materia medica RS1-441
Zdroj:	Brazilian Journal of Pharmaceutical Sciences, Vol 52, Iss 4, Pp 709-714
Druh dokumentu:	article
ISSN:	2175-9790 1984-8250
DOI:	10.1590/s1984-82502016000400015
Popis:	ABSTRACT The Maillard reaction of hydrochlorothiazide (HCTZ) and lactose has been previously demonstrated in pharmaceutical formulations. In this study, the activation energy of - hydrohlorothiazide and lactose interaction in the liquid state was ascertained under basic and neutral conditions. Conventional isothermal High Performance Liquid Chromatography (HPLC) technique was employed to ascertain the kinetic parameters using Arrhenius method. Results: The activation energy obtained was 82.43 and 100.28 kJ/mol under basic and neutral conditions, respectively. Consequently, it can be inferred that Maillard reaction is significantly affected by pH, which can be used as a control factor whenever the reaction potentially occurs.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/01afb75134ca4898814a26098dff8807 Zobrazit plný text záznamu View record in DOAJ