With low ovarian reserve, Highly Individualized Egg Retrieval (HIER) improves IVF results by avoiding premature luteinization

Autor:	Yan-Guang Wu, David H. Barad, Vitaly A. Kushnir, Qi Wang, Lin Zhang, Sarah K. Darmon, David F. Albertini, Norbert Gleicher
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	In vitro fertilization (IVF) Advanced female age Premature ovarian aging (POA) Occult primary ovarian insufficiency (oPOI) Pregnancy rates Premature luteinization Gynecology and obstetrics RG1-991
Zdroj:	Journal of Ovarian Research, Vol 11, Iss 1, Pp 1-7 (2018)
Druh dokumentu:	article
ISSN:	1757-2215
DOI:	10.1186/s13048-018-0398-8
Popis:	Abstract Background Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be for administration of ovulation-triggers. Methods Fifty-six women ≥43, and 37 POA patients underwent IVF cycles. Granulosa cells (GCs) were isolated, cultures were established, RNA was extracted and real-time PCR analyses performed, with gene expressions at mRNA level investigated for FSH receptor (FSHR), luteinizing hormone receptor (LHCPR), P450 aromatase (CYP19a1) and progesterone receptor (PGR). POA was defined by age
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/01a2d364f8ba477cba086ec9b9125b78 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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