| Autor: |
Francesca Bertolini, Tainã Figueiredo Cardoso, Gabriele Marras, Ezequiel L. Nicolazzi, Max F. Rothschild, Marcel Amills, the AdaptMap consortium |
| Jazyk: |
German<br />English<br />French |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Genetics Selection Evolution, Vol 50, Iss 1, Pp 1-12 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1297-9686 |
| DOI: |
10.1186/s12711-018-0424-8 |
| Popis: |
Abstract Background Patterns of homozygosity can be influenced by several factors, such as demography, recombination, and selection. Using the goat SNP50 BeadChip, we genotyped 3171 goats belonging to 117 populations with a worldwide distribution. Our objectives were to characterize the number and length of runs of homozygosity (ROH) and to detect ROH hotspots in order to gain new insights into the consequences of neutral and selection processes on the genome-wide homozygosity patterns of goats. Results The proportion of the goat genome covered by ROH is, in general, less than 15% with an inverse relationship between ROH length and frequency i.e. short ROH ( 0.20) F ROH values. For populations from Asia, the average number of ROH is smaller and their coverage is lower in goats from the Near East than in goats from Central Asia, which is consistent with the role of the Fertile Crescent as the primary centre of goat domestication. We also observed that local breeds with small population sizes tend to have a larger fraction of the genome covered by ROH compared to breeds with tens or hundreds of thousands of individuals. Five regions on three goat chromosomes i.e. 11, 12 and 18, contain ROH hotspots that overlap with signatures of selection. Conclusions Patterns of homozygosity (average number of ROH of 77 and genome coverage of 248 Mb; F ROH |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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