| Autor: |
Sandra Ropret, Preeti Khurana, Tara Fabčič, Janina Cvetkovska, Ana Trobec, Špela Zemljič Jokhadar, Dusko Ilic, John A McGrath, Christina Guttmann-Gruber, Mirjana Liovic |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Stem Cell Research, Vol 75, Iss , Pp 103306- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2024.103306 |
| Popis: |
We have generated MLi005-A, a new induced pluripotent stem cell (iPSC) line derived from skin fibroblasts of a male patient with dominant dystrophic epidermolysis bullosa (DDEB). This iPSC line may be used as a model system for studies on skin integrity, the extracellular matrix and skin barrier function. The characterization of the MLi005-A cell line consisted of molecular karyotyping, next-generation sequencing of the COL7A1 alleles, pluripotency and differentiation potentials testing by immunofluorescence of associated markers in vitro. The MLi-005A line has been also tested for ability to differentiate into fibroblasts and keratinocytes and markers associated with these cell types. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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