Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry

Autor:	Marc-André Delsuc, Kathrin Breuker, Maria A. van Agthoven
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	mass spectrometry two-dimensional tandem mass spectrometry phase correction absorption mode data processing Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 11, p 3388 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26113388
Popis:	Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass spectra are obtained by performing a Fourier transform in both the precursor ion mass-to-charge ratio (m/z) dimension and the fragment ion m/z dimension. The phase of the ion signals evolves linearly in the precursor m/z dimension and quadratically in the fragment m/z dimension. This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode. Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation.
Databáze:	Directory of Open Access Journals
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