Multifunctional Nanoparticles and Nanoclusters as a Theranostics and Symptoms Disappearing Agent for Traumatic Brain Injury

Autor: Fong LaiGuan Zoey, Krishna Kanta Ghosh, Mathangi Palanivel, Balázs Gulyás, Parasuraman Padmanabhan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Advanced NanoBiomed Research, Vol 3, Iss 12, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2699-9307
20230001
DOI: 10.1002/anbr.202300010
Popis: Traumatic brain injury (TBI) is one of the most common causes of disability and mortality worldwide, creating a large socioeconomic burden annually. Secondary injury physiopathology is known to play a prominent role in exacerbating neurodegeneration post‐TBI and is potentially preventable by therapies. However, due to the heterogeneity of TBI and the complexity of the pathological mechanisms that ensue, there are currently no effective disease‐modifying treatments to prevent TBI‐associated disability and mortality. Nanotechnology has emerged in recent decades as a promising platform for the development of multifunctional neuroprotective agents for TBI. Herein, current multifunctional innovations are explored in this review in nanotechnology, which target the secondary injury pathological mechanisms of TBI and show promise in improving future post‐TBI management. Also, potential new directions for the future development of TBI treatment are discussed.
Databáze: Directory of Open Access Journals
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