Doxorubicin-loaded polymeric nanoparticles containing ketoester-based block and cholesterol moiety as specific vehicles to fight estrogen-dependent breast cancer

Autor:	Paweł Misiak, Katarzyna Niemirowicz-Laskowska, Karolina H. Markiewicz, Przemysław Wielgat, Izabela Kurowska, Robert Czarnomysy, Iwona Misztalewska-Turkowicz, Halina Car, Krzysztof Bielawski, Agnieszka Z. Wilczewska
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Polymeric nanoparticles Cholesterol-end capped poly(N-isopropylacrylamide) Cell-penetrating molecules Breast cancer Doxorubicin Smart drug delivery systems Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-25 (2023)
Druh dokumentu:	article
ISSN:	1868-6958 1868-6966
DOI:	10.1186/s12645-023-00176-9
Popis:	Highlights 1. DDS based on cholesterol, ketoester, and NIPAAm, designed for the delivery of DOX. 2. The ketoester and arrangement of blocks are crucial for anticancer activity. 3. PNPs not only act as transporters but also sensitize the cell to DOX. 4. High cytotoxicity of DOX-loaded PNPs was achieved despite low doses of the drug. 5. PNPs have the proper size, shape, and ζ potential for efficient drug delivery.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/019217dfb4c6466c857824351eaface4 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ