Biomarkers of Air-Blood Barrier Damage In COVID-19
| Autor: | M. B. Khadzhieva, A. S. Gracheva, A. V. Ershov, Yu. V. Chursinova, V. A. Stepanov, L. S. Avdeikina, O. A. Grebenchikov, A. S. Babkina, A. K. Shabanov, A. V. Tutelyan, S. S. Petrikov, A. N. Kuzovlev |
|---|---|
| Jazyk: | English<br />Russian |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Общая реаниматология, Vol 17, Iss 3, Pp 16-31 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1813-9779 2411-7110 |
| DOI: | 10.15360/1813-9779-2021-3-2-0 |
| Popis: | The search for sensitive and specific markers enabling timely identification of patients with a life-threatening novel coronavirus infection (COVID-19) is important for a successful treatment.The aim of the study was to examine the association of molecular biomarkers of air-blood barrier damage, surfactant proteins SP-A and SP-D and Club cell protein CC16, with the outcome of patients with COVID-19.Materials and methods. A cohort of 109 patients diagnosed with COVID-19 was retrospectively divided into two groups. Group 1 comprised survivor patients discharged from the ICU (w=90). Group 2 included the patients who did not survive (w=19). Association of disease outcome and SP-A, SP-D, and CC16 levels in blood serum, clinical, and laboratory data were examined taking into account the day of illness at the time of biomaterial collection.Results. The non-survivors had higher SP-A (from days 1 to 10 of symptoms onset) and lower CC16 (from days 11 to 20 of symptoms onset) levels vs survivors discharged from ICU. No significant differences in SP-D levels between the groups were found.Conclusion. According to the study results, the surfactant protein SP-A and Club cell protein CC16 are associated with increased COVID-19 mortality. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|