Evaluation of the impact of marijuana use on semen quality: a prospective analysis
| Autor: | Marah C. Hehemann, Omer A. Raheem, Saneal Rajanahally, Sarah Holt, Tony Chen, Judy N. Fustok, Kelly Song, Heather Rylander, Emma Chow, Kevin A. Ostrowski, Charles H. Muller, Thomas J. Walsh |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Urology, Vol 13 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1756-2880 17562872 |
| DOI: | 10.1177/17562872211032484 |
| Popis: | Aims: To assess if marijuana consumption – prevalent among men of reproductive age and becoming widespread due to decriminalization – is associated with changes in semen parameters. Marijuana’s active metabolite, tetrahydrocannabinol, can alter signaling pathways within spermatozoa, affecting spermatogenesis and fertility. Methods: We prospectively evaluated semen analyses (SA) from men presenting for infertility evaluation at one institution from July 2017 to April 2018. Participants completed a reproductive health questionnaire including items regarding marijuana consumption. SA was performed in accordance with World Health Organization (WHO) 5th Edition criteria. SA parameters included volume (ml), concentration (million/ml), motility (%), progressive motility (%), and Tygerberg strict morphology (%). Results: A total of 409 patients completed the questionnaire; 174 (43%) men reported marijuana use (ever-users). Current and past users comprised 71 (17%) and 103 (25%), respectively. Compared with never-users, current and past users had a significantly higher likelihood of abnormal sperm strict morphology (33.1% versus 50.7% and 53.4%, respectively; p |
| Databáze: | Directory of Open Access Journals |
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