Single Tablet Regimen Usage and Efficacy in the Treatment of HIV Infection in Australia
| Autor: | B. Armstrong, D. J. Chan, M. J. Stewart, D. Fagan, D. Smith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | AIDS Research and Treatment, Vol 2015 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2090-1240 2090-1259 |
| DOI: | 10.1155/2015/570316 |
| Popis: | Single tablet regimens (STRs) for HIV infection improve patient satisfaction, quality of life, medication adherence, and virological suppression compared to multitablet regimens (MTRs). This is the first study assessing STR uptake and durability in Australia. This retrospective audit of all patients receiving an STR (n=299) at a large Sydney HIV clinic (January 2012–December 2013) assessed patient demographics, treatment prior to STR, HIV RNA load and CD4 during MTR and STR dosing, and reasons for STR switch. 206 patients switched from previous antiretroviral treatment to an STR, of which 88% switched from an MTR. Reasons for switching included desire to simplify treatment (57%), reduced side effects or toxicity (18%), and cost-saving for the patient. There was no switching for virological failure. Compared to when on an MTR, patients switching to an STR had significantly lower HIV RNA counts (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|