GPR30 Selective Agonist G1 Exhibits Antiobesity Effects and Promotes Insulin Resistance and Gluconeogenesis in Postmenopausal Mice Fed a High-Fat Diet

Autor: Da Liu, Mingqi Zheng, Congcong Lu, Mengdan Miao, Yinge Zhan, Fangfang Ma, Yajuan Yin, Mei Wei, Wei Wang, Wenyao Wang, Xiangbin Meng, Jing Li, Yaohua Zhang, Gang Liu, Yi-Da Tang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Lipids, Vol 2024 (2024)
Druh dokumentu: article
ISSN: 2090-3049
DOI: 10.1155/2024/5513473
Popis: Conclusions: These findings indicate that G1 treatment is influenced by a high-fat diet, potentially disrupting glucolipid metabolism and promoting insulin resistance alongside its antiobesity effects. Consequently, further investigation is imperative to thoroughly explore this potential toxic side effect of G1 therapy.
Databáze: Directory of Open Access Journals
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