Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity

Autor:	Todorovic Vesna, Groselj Blaz, Cemazar Maja, Prevc Ajda, Zakelj Martina Niksic, Strojan Primoz, Sersa Gregor
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	head and neck cancer squamous cell carcinoma radioresistance irradiation dna-damaging agents gene expression profiles Medical physics. Medical radiology. Nuclear medicine R895-920
Zdroj:	Radiology and Oncology, Vol 56, Iss 2, Pp 173-184 (2022)
Druh dokumentu:	article
ISSN:	1581-3207 2022-0014
DOI:	10.2478/raon-2022-0014
Popis:	Increased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging agents plays a crucial role in determining the fate of exposed cells. Tightly regulated and interconnected signaling networks are activated to detect, signal the presence of and repair the DNA damage. Novel therapies targeting the DNA-damage response are emerging; however, an improved understanding of the complex signaling networks involved in tumor radioresistance and radiosensitivity is needed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cc01565e70bb4fc192a41b9b2df028b8 Zobrazit plný text záznamu View record in DOAJ