Clinical effects of probiotic or azithromycin as an adjunct to scaling and root planning in the treatment of stage III periodontitis: a pilot randomized controlled clinical trial

Autor: Alicia Morales, Rafael Contador, Joel Bravo, Paola Carvajal, Nora Silva, Franz-Josef Strauss, Jorge Gamonal
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Oral Health, Vol 21, Iss 1, Pp 1-15 (2021)
Druh dokumentu: article
ISSN: 1472-6831
DOI: 10.1186/s12903-020-01276-3
Popis: Abstract Background The aim of this triple-blind placebo-controlled parallel-arm randomized clinical trial was to evaluate the clinical effects of Lactobacillus rhamnosus SP1 or azithromycin as an adjunct to scaling and root planing (SRP) in patients with stage III periodontitis. Methods Forty-seven systemically healthy participants with stage III periodontitis were recruited. Following SRP, the participants were randomly assigned to one of three treatment modalities; (1) placebo (n = 15), (2) probiotics (n = 16) and (3) antibiotics-azithromycin (n = 16). The participants were monitored at baseline, 3, 6, 9 and 12 months after therapy. Probing pocket depth (PPD), bleeding on probing (BOP), clinical attachment loss (CAL) and plaque accumulation (PI) were evaluated. Results All 47 participants completed the study. At 12 months, all groups showed significant improvements of PPD and PI (p
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