| Autor: |
Edson L.P. Camandaroba, Eliana A.G. Reis, Marilda S. Gonçalves, Mitermayer G. Reis, Sonia G. Andrade |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 2, Pp 201-209 (2003) |
| Druh dokumentu: |
article |
| ISSN: |
1678-9849 |
| Popis: |
The present investigation was performed to evaluate the susceptibility of seven clones isolated from the highly resistant Colombian strains, prototype of Biodeme Type III. Seven clones previously obtained, showed a phenotypic homogeneity and high similarity with the parental strain. Eight groups of 30 mice were inoculated with one of seven clones or the parental strain; 20 were treated with benznidazole (100mg/kg/day) and 10 were untreated controls. Cure evaluations were done by parasitological and serological tests and PCR. Cure rates varied from 0% (null) to 16.7%. Correlation between positivity of parasitological and serological tests with positive PCR reached 37%. The results demonstrated the high resistance of the clones, suggesting the predominance of a highly resistant principal clone in this strain. The findings apparently indicate that the possibility of cure is minimal for patients infected with this biodeme; a fact that could affect the control of Chagas' disease through treatment of chronically infected people. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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