Interplay between Vitamin D and Sphingolipids in Cardiometabolic Diseases

Autor:	Simona Fenizia, Melania Gaggini, Cristina Vassalle
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	1 25-dihydroxyvitamin D sphingolipids ceramides sphingosine 1-phosphate vitamin D calcitriol Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 24, Iss 23, p 17123 (2023)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms242317123
Popis:	Sphingolipids (SLs) are structural, bioactive molecules with several key cellular roles, whereas 1,25-dihydroxyvitamin D (1,25(OH)D), the active form of vitamin D, is considered the major regulator of calcium homeostasis, although it also exerts other extraskeletal effects. Many studies reported the physiological connection between vitamin D and SLs, highlighting not only the effects of vitamin D on SL metabolism and signaling but also the influence of SLs on vitamin D levels and function, thus strongly suggesting a crosstalk between these molecules. After a brief description of 1,25(OH)D and SL metabolism, this review aims to discuss the preclinical and clinical evidence on the crosstalk between SLs and 1,25(OH)D, with a special focus on cardiometabolic diseases.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e013c169967a480f89cd60e1b9d0e775 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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