| Popis: |
BackgroundLittle is known about how the residential distance to the coast is associated with incident myocardial infarction (MI) and which mechanisms may explain the association. We aim to explore this association using data from a prospective, population-based cohort with unprecedented sample size, and broad geographical coverage.MethodsIn this study, 377,340 participants from the UK Biobank were included.ResultsIt was shown that 4,059 MI occurred during a median 8.0 years follow-up. Using group (64 km) were both associated with a higher risk of incident MI (HR 1.12, 95% CI 1.04–1.21 and HR 1.09, 95% CI 1.01–1.18, respectively). HR for offshore region (64 km) was larger in subgroup in urban area (HR 1.12, 95% CI 1.03–1.22, pinteraction = 0.065) and in subgroup of high nitrogen dioxide (NO2) air pollution (HR 1.29, 95% CI 1.11–1.50, pinteraction = 0.021).ConclusionWe found a U-shaped association between residential distance to the coast and incident MI, and the association was modified by physical activity, population density, and air pollution. |
