Hydrothermal Synthesis, Structural Characterization, and Interaction Mechanism with DNA of Copper(II) Complex Containing 2,2′-Bipyridine

Autor: Ting Liu, Yi-An Wang, Qing Zang, Guo-Qing Zhong
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Bioinorganic Chemistry and Applications, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 1565-3633
1687-479X
DOI: 10.1155/2018/8459638
Popis: A Cu(II) complex [Cu(bipy)(H2O)2(SO4)]n (bipy = 2,2′-bipyridine) was synthesized by hydrothermal method and characterized structurally by elemental analyses, single crystal X-ray diffraction, infrared spectra, and thermogravimetry and differential scanning calorimetry. The Cu(II) was hexacoordinated by two N atoms from bipy, two O atoms from different sulfate radical anions, and two O atoms from two water molecules, forming a slightly distorted octahedral geometry, and bridged by sulfato groups into polymeric chains. Under the condition of physiological pH, the interaction mechanism between the complex and hsDNA was explored with acridine orange as a fluorescence probe by spectroscopic methods. The binding modes between the complex and hsDNA were the electrostatic and embedded modes.
Databáze: Directory of Open Access Journals
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