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Wei Wang,1,2 Yi Zhang,3 Runzi Wang,1,2 Yeshaswi Shrestha,1,2 Yawei Xu,3 Luying Peng,1,4,5 Jie Zhang,1,2 Jue Li,1,2 Lijuan Zhang1,2 1Key Laboratory of Arrhythmias of the Ministry of Education, Tongji University School of Medicine, Shanghai 200092, People’s Republic of China; 2Institute of Clinical Epidemiology and Evidence-Based Medicine, Tongji University School of Medicine, Shanghai 200092, People’s Republic of China; 3Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China; 4Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092, People’s Republic of China; 5Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of ChinaCorrespondence: Jue Li; Lijuan ZhangKey Laboratory of Arrhythmias of the Ministry of Education, Tongji University School of Medicine, Shanghai 200092, People’s Republic of ChinaTel/fax +86 21 65985195Email jueli@tongji.edu.cn; zhangxiaoyi@tongji.edu.cnPurpose: Left ventricular diastolic dysfunction with preserved ejection fraction (LVDD-PEF) is an early-stage manifestation but poorly understood in the process of heart failure. This study was designed to investigate risk factors and epigenetic markers for predicting LVDD-PEF.Patients and methods: A community-based study in 1568 residents over 65 years was conducted in Shanghai, People’s Republic of China, from June 2014 to August 2015. Echocardiography was performed to diagnose LVDD-PEF. DNA methylation by whole-genome bisulfite sequencing was used to determine those potential epigenetic markers contributing to LVDD-PEF.Results: A total of 177 participants (11.3%) were diagnosed with LVDD-PEF, and higher prevalence in females than in males (15.0% vs 6.5%, P |
