Secondary Metabolites, including a New 5,6-Dihydropyran-2-One, Produced by the Fungus Diplodia corticola. Aphicidal Activity of the Main Metabolite, Sphaeropsidin A

Autor:	Maria Michela Salvatore, Ilaria Di Lelio, Marina DellaGreca, Rosario Nicoletti, Francesco Salvatore, Elia Russo, Gennaro Volpe, Andrea Becchimanzi, Alla Eddine Mahamedi, Akila Berraf-Tebbal, Anna Andolfi
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	fungal metabolites botryosphaeriaceae metabolomics natural products sphaeropsidins Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 7, p 2327 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27072327
Popis:	An undescribed 5,6-dihydropyran-2-one, namely diplopyrone C, was isolated and characterized from the cultures of an isolate of the fungus Diplodia corticola recovered from Quercus suber in Algeria. The structure and relative stereostructure of (5S,6S,7Z,9S,10S)-5-hydroxy-6-(2-(3-methyloxiran-2-yl)vinyl)-5,6-dihydro-2H-pyran-2-one were assigned essentially based on NMR and MS data. Furthermore, ten known compounds were isolated and identified in the same cultures. The most abundant product, the tetracyclic pimarane diterpene sphaeropsidin A, was tested for insecticidal effects against the model sucking aphid, Acyrthosiphon pisum. Results showed a toxic dose-dependent oral activity of sphaeropsidin A, with an LC50 of 9.64 mM.
Databáze:	Directory of Open Access Journals
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