Targeting HER 1 and 2 in breast cancer with lapatinib

Autor: Gerald M. Higa
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Oncology Reviews, Vol 2, Iss 1, Pp 21-28 (2011)
Druh dokumentu: article
ISSN: 1970-5557
1970-5565
Popis: Numerous clinical trials support the biological relevance of the HER2 oncoprotein in breast cancer. In spite of improved outcomes, overexpression of the receptor is associated with increased risks of disease relapse, even in patients with early, and potentially curable, disease. Until recently, development of resistance to trastuzumab left patients with no therapeutic option other than specifically targeted HER2. This paper provides an in-depth review of lapatinib, a dual HER kinase inhibitor, as well as some insight into three HER family members, in breast cancer.
Databáze: Directory of Open Access Journals
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