| Autor: |
Enoluomen Ben Ehigiator, Elias Adikwu, Anthony Chiwendu Ifeduba |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Clinical and Basic Research, Vol 6, Iss 3, Pp 23-26 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2538-3736 |
| Popis: |
Background and objectives: Bisphenol A (BPA) can impair kidney function via oxidative stress. Glutamine (Gln) is an amino acid with antioxidant and immunomodulatory activities. This study assessed the protective activity of Gln against BPA-induced nephrotoxicity in rats. Methods: Thirty adult male Wistar rats (200-230g) were randomly divided into 6 groups (each containing 5 rats). The rats were orally treated daily for 60 days as follows: Groups A (Control), B, and C were treated with normal saline (0.2 mL), Gln (80 mg/kg), and BPA (50 mg/kg), respectively. Groups D-F were supplemented with 20 mg/kg, 40 mg/kg, and 80 mg/kg of Gln before treatment with BPA (50 mg/kg), respectively. Blood samples were collected and serum renal biochemical markers were measured. The kidneys were weighed and evaluated for oxidative stress markers and histological changes. Results: Administration of BPA decreased body weight (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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