Atopic dermatitis-like skin lesions are suppressed in fat-1 transgenic mice through the inhibition of inflammasomes
| Autor: | Hyun-Young Jang, Jeung-Hyun Koo, Sang-Myeong Lee, Byung-Hyun Park |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Experimental and Molecular Medicine, Vol 50, Iss 6, Pp 1-9 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1226-3613 2092-6413 |
| DOI: | 10.1038/s12276-018-0104-3 |
| Popis: | Skin disease: Omega-3 fatty acid reduces inflammation A component of fish oil reduces the severity of atopic dermatitis in mice by dampening the immune response. Omega-3 fatty acids found in fish oil are essential nutrients that humans and other mammals need but cannot produce. Byung-Hyun Park at Chonbuk National University Medical School, Jeonju, South Korea, and colleagues show that genetically engineered mice expressing a gene which enables them to synthesize their own omega-3 fatty acids are protected from atopic dermatitis. Following exposure to a dermatitis-inducing chemical or house dust mite extract these mice developed smaller skin lesions and mounted a weaker inflammatory response than wild-type mice. This study confirms the anti-inflammatory effects of omega-3 fatty acids and highlights the use of fish oil supplements as a useful strategy for the treatment of atopic dermatitis and potentially other chronic inflammatory diseases. |
| Databáze: | Directory of Open Access Journals |
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