| Autor: |
Youn I Choi, Jun-Won Chung, Dong Kyun Park, Kyoung Oh Kim, Kwang An Kwon, Yoon Jae Kim, Su Young Kim, Sung-Min Ahn, Mun-Deok Han, Kwang-Pil Ko |
| Jazyk: |
English<br />Korean |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, Vol 20, Iss 1, Pp 47-53 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1738-3331 |
| DOI: |
10.7704/kjhugr.2019.0027 |
| Popis: |
Background/Aims Although proton pump inhibitors (PPIs) remain a mainstay for the suppression of gastric acid secretion, long-term PPI use is associated with side effects. However, the genotoxicity associated with long-term PPI use is unclear. Materials and Methods This prospective observational pilot study enrolled patients who had been on PPIs for >1 year and healthy controls from July 2015 to August 2016. The subjects completed self-report questionnaires pertaining to their drug and medical history, and only those with no medical history and a ≥2-year wash-out period (for drugs other than PPIs) were included. We collected peripheral-blood lymphocytes from long-term PPI users and healthy controls and analyzed the genotoxicity by using the cytokinesis-block micronucleus cytome assay; we also determined the fasting serum levels of pyridoxine, folate, cobalamin, and homocysteine. Results Ten long-term PPI users and 40 healthy control subjects were enrolled. The median serum pyridoxine, folate, cobalamin, and homocysteine levels were not significantly different between the groups. The median frequencies of micronuclei (MNi), nucleoplasmic bridges (NPBs), and nuclear buds (Nbuds) per 1,000 binucleated cells, in long-term PPI users and healthy controls, were 30.3 and 16.3 (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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