| Autor: |
Laura C. McCoullough, Margaret Littlejohn, Peter A. Revill |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Exploration of Digestive Diseases, Vol 3, Iss 4, Pp 326-343 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2833-6321 |
| DOI: |
10.37349/edd.2024.00054 |
| Popis: |
Chronic hepatitis B (CHB) disease caused by persistent infection with hepatitis B virus (HBV) is a global health problem affecting almost 300 million people worldwide, resulting in up to 1 million deaths each year. The factors contributing to HBV mediated liver disease are yet to be fully resolved, however, multiple studies have suggested that HBV splice variants may be a contributing factor. Recent studies have indicated that novel fusion proteins encoded by splice variants, or the splice-derived RNA itself, may impact replication of wild-type HBV, although the direct mechanisms for these interactions are largely unknown. This review explores the latest knowledge regarding the contribution of splice variants to liver disease and their impact on HBV replication. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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