Dramatic Response of Lupus Enteritis, Nephritis, and Pancytopenia to Plasmapheresis and Rituximab

Autor: Adan Aftab, Nida Saleem, Syed Farhat Abbas, Zafar Ullah, Muhammad Haneef
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Case Reports in Gastrointestinal Medicine, Vol 2022 (2022)
Druh dokumentu: article
ISSN: 2090-6536
DOI: 10.1155/2022/3443141
Popis: Background. Although lupus enteritis is a rare manifestation of systemic lupus erythematosus yet results in significant distress. This disorder contributes to diagnostic and therapeutic dilemma leading to enhanced mortality. Case Description. We report a case history of a 29-year-old female who presented with severe abdominal pain, watery stools, and vomiting, and later on, she developed pancytopenia and renal impairment. On intensive workup, diagnosis of lupus-associated enteritis, nephritis, and pancytopenia was discovered. She improved drastically on initiation of plasmapheresis followed by low-dose intravenous rituximab. One year posttreatment, she remained in complete remission. Conclusion. From this case, it can be suggested that in a young female with intractable abdominal pain, the remote possibility of lupus enteritis must be kept in mind. Besides this, plasmapheresis can have a potential role in refractory lupus enteritis. Furthermore, low-dose intravenous rituximab can be a safe and cost-effective treatment option in achieving sustained remission of clinical and laboratory parameters in lupus enteritis.
Databáze: Directory of Open Access Journals
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