| Autor: |
Shiro Takeda, Muneaki Hidaka, Hiroki Yoshida, Masahiko Takeshita, Yukiharu Kikuchi, Chuluunbat Tsend-Ayush, Bumbein Dashnyam, Satoshi Kawahara, Michio Muguruma, Wataru Watanabe, Masahiko Kurokawa |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 9, Iss , Pp 60-69 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2014.04.013 |
| Popis: |
Antiallergic activities of 10 lactic acid bacteria strains prepared from Mongolian dairy products as orally administered probiotics were examined in three murine type I allergy models (compound 48/80 stimulation, passive cutaneous anaphylaxis reaction, and ovalbumin sensitization models). Among the 10, only Lactobacillus plantarum strain 06CC2 significantly alleviated allergic symptoms in all three models and reduced the levels of total IgE, ovalbumin-specific IgE, and histamine in the sera of ovalbumin-sensitized mice. In vitro study, interferon-γ and interleukin-4 secretions from spleen cells of ovalbumin-sensitized mice administered the 06CC2 strain were significantly enhanced and suppressed, respectively, in the presence of ovalbumin. In Peyer's patches of ovalbumin-sensitized mice, strain 06CC2 significantly enhanced mRNA expressions of interferon-γ and interleukin-12 receptor β2, but suppressed that of the interleukin-4. Thus, strain 06CC2 probably promoted Th1 immunity through intestinal immunity and improved the Th1/Th2 balance in type I allergic mice, resulting in alleviation of allergic symptoms. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect