Second primary breast cancer after diagnosis of breast cancer among male patients: An examination of population characteristics and overall survival

Autor: Amit K. Chowdhry, Divya N. Chowdhry, Michelle Shayne, Michael T. Milano
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: EClinicalMedicine, Vol 27, Iss , Pp 100551- (2020)
Druh dokumentu: article
ISSN: 2589-5370
DOI: 10.1016/j.eclinm.2020.100551
Popis: Background: Male patients with breast cancer (BrC) have increased risk of developing 2nd-primary BrC (2nd-BrC). Given the relative rarity of male BrC, population-based registries are needed to analyze overall survival (OS) outcomes for these patients. Methods: Using the Surveillance, Epidemiology and End Results registry of patients diagnosed from 1975 to 2016, a cohort study of men whose only malignancy was BrC (BrCO; n = 6,475), and men who developed 2nd-BrC after initial BrC diagnosis (BrC-2; n = 85) was performed. The standardized incidence ratio (SIR) of 2nd-BrC, Kaplan-Meier OS and multivariable Cox regression modelling were performed. Findings: The SIR for 2nd-BrC was 32.95 (95%CI:[23.85–44.38],p
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