The Impact of the Coexpression of MET and ESR Genes on Prognosticators and Clinical Outcomes of Breast Cancer: An Analysis for the METABRIC Dataset

Autor:	Nehad M. Ayoub, Ghaith M. Al-Taani, Amer E. Alkhalifa, Dalia R. Ibrahim, Aymen Shatnawi
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Public aspects of medicine RA1-1270
Zdroj:	The Breast Journal, Vol 2024 (2024)
Druh dokumentu:	article
ISSN:	1524-4741
DOI:	10.1155/2024/2582341
Popis:	Purpose. Breast cancer is a heterogeneous disease. Exploring new prognostic and therapeutic targets in patients with breast cancer is essential. This study investigated the expression of MET, ESR1, and ESR2 genes and their association with clinicopathologic characteristics and clinical outcomes in patients with breast cancer. Methods. The METABRIC dataset for breast cancer was obtained from the cBioPortal public domain. Gene expression data for MET, ESR1, and ESR2, as well as the putative copy number alterations (CNAs) for MET were retrieved. Results. The MET mRNA expression levels correlated inversely with the expression levels of ESR1 and positively with the expression levels of ESR2 (r = −0.379, p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/00c853a6939843a8bd58d92b693bdcee Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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