Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology

Autor:	A. V. Tarasiuk, Y. V. Mezentsev, O. V. Gnedenko, P. Yu. Povarnina, A. S. Ivanov
Jazyk:	ruština
Rok vydání:	2023
Předmět:	neurotrophin bdnf trkb dimeric dipeptide mimetic optical biosensor surface plasmon resonance Pharmacy and materia medica RS1-441
Zdroj:	Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 50-54 (2023)
Druh dokumentu:	article
ISSN:	2587-7836 2686-8830
DOI:	10.37489/2587-7836-2022-4-50-54
Popis:	The interaction of the neurotrophin BDNF dipeptide mimetic, compound GSB-106, with the tyrosine kinase TrkB receptor specific for the fullsized neurotrophin was studied using surface plasmon resonance. The significant decrease in the binding of BDNF to TrkB, which was preincubated with GSB-106, was shown. The obtained data indicate the interaction of GSB-106 with the TrkB receptor.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/00c2a6dcdaad4c679147cb8df67df9d3 Zobrazit plný text záznamu View record in DOAJ