The alteration of intrauterine microbiota in chronic endometritis patients based on 16S rRNA sequencing analysis

Autor: Qing Chen, Xiaowei Zhang, Qicai Hu, Wei Zhang, Yi Xie, Weixia Wei
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Annals of Clinical Microbiology and Antimicrobials, Vol 22, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 1476-0711
DOI: 10.1186/s12941-023-00556-4
Popis: Abstract Background Chronic endometritis (CE) is a disease of continuous and subtle inflammation occurring in the endometrial stromal area, which is often asymptomatic or present with non-specific clinical symptoms. Methods This study investigated the composition and distribution of the intrauterine microbiota of 71 patients who underwent hysteroscopy during the routine clinical inspection of infertility. Among them, patients who were diagnosed with chronic endometritis (CE) were allocated into CE group (n = 29) and others into non-CE group (n = 42). There was no significant difference in average age between the two groups (P = 0.19). Uterine flushing fluid was collected by the self-developed cervical trocar uterine cavity sampler and 16S rRNA sequencing was performed. Results The alpha diversity in the CE group was significantly higher than that in the non-CE group (P
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