IFNL4 genotype influences the rate of HIV-1 seroconversion in men who have sex with men
| Autor: | Giovanna Meza, Fátima Galián, Claudia Jaimes-Bernal, Francisco J. Márquez, Faruk Sinangil, Carolina Scagnolari, Luis Miguel Real, Donald Forthal, Antonio Caruz |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Virulence, Vol 13, Iss 1, Pp 757-763 (2022) |
| Druh dokumentu: | article |
| ISSN: | 21505594 2150-5608 2150-5594 |
| DOI: | 10.1080/21505594.2022.2066612 |
| Popis: | Individuals lacking interferon lambda 4 (IFNL4) protein due to a common null mutation (rs368234815) in the IFNL4 gene display higher resistance against several infections. The influence of IFNL4 on HIV-1 infection is still under discussion and conflicting results have been reported. This study intended to corroborate or refute the association of the null allele of IFNL4 and HIV-1 predisposition in a cohort of men who have sex with men (MSM). IFNL4 null genotype was assessed on 619 HIV-1-seronegative MSM who were followed for 36 months during a trial of a prophylactic vaccine against HIV-1. Of those, 257 individuals seroconverted during this period. A logistic regression model was constructed including demographic and IFNL4 genotype. In addition, a meta-analysis using data from the current study and other European populations was conducted. The null IFNL4 genotypes were correlated with lower HIV-1 seroconversion (Adjusted OR = 0.4 [95%CI: 0.2–0.8], P = 0.008) and longer time to seroconversion (889 vs. 938 days, P= 0.01). These results were validated by a meta-analysis incorporating data from other European populations and the result yielded a significant association of the IFNL4 null genotype under a dominant model with a lower probability of HIV-1 infection (OR=0.4 [95% CI: 0.3-0.6]; P= 1.3 x 10E-5). |
| Databáze: | Directory of Open Access Journals |
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