| Autor: |
Dr Yasir Naqi Khan, Dr Muhammad Ashfaq, Dr Bader-u-Nisa, Dr Mehrunnisa Yasir, Dr Hira Waseem, Muhammad Adnan Kanpurwala |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, Vol 26, Iss 3 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1563-3241 |
| DOI: |
10.58397/ashkmdc.v26i3.474 |
| Popis: |
Objective: Diabetes mellitus (DM) is a complicated, prolonged metabolic disorder that leads to hyperglycemia and it occurrs due to complete deficiency of insulin with or with insulin resistance. The most common type of DM in children and adolescents is Type-1 DM (T1DM). The aim of this study was to determine the associations of IAA, GAD65 and IA-2A antibodies in type 1 diabetes mellitus with age, gender and duration of disease. Methodology: This was a retrospective study conducted in the NICH hospital at the department of endocrinology and diabetes by using non probability consecutive sampling technique, after taking ethical approval. The duration of the study was one year. A total of 143 patients with clinically diagnosed type 1 diabetes ( ?1 year to ?20 years of age, regardless of the duration of the disease) were selected for the study. All study subjects were investigated for pancreatic autoimmune markers (GAD65, IA-2A, IAAs). Pearson’s Chi square test was applied to evaluate the association. Results: A total of 143 children diagnosed with type 1 diabetes were enrolled for this study wherein 71(49.7%) were males and 72(50.3%) were females. Regarding the distribution of positivity of autoantibodies, 27(18.9%) had AntiInsulin IgG, 63(44.1%) had GAD65, 47(32.9%) had IA-2A and only 5(3.5%) had grey zone. There was a significant association was reported (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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