The influence of psychological stress in early life on sexual maturation and sexual behavior in male and female rats

Autor: Kiyohito Yano, Toshiya Matsuzaki, Takeshi Iwasa, Yiliyasi Mayila, Rie Yanagihara, Altankhuu Tungalagsuvd, Munkhsaihan Munkhzaya, Takako Tokui, Shuhei Kamada, Aki Hayashi, Rie Masaki, Hidenori Aoki, Kou Tamura, Minoru Irahara
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Reproductive Medicine and Biology, Vol 19, Iss 2, Pp 135-141 (2020)
Druh dokumentu: article
ISSN: 1447-0578
1445-5781
DOI: 10.1002/rmb2.12313
Popis: Abstract Purpose We studied the influence of psychological stress during the early neonatal period on sexual maturation and sexual behavior in rats. Methods Neonatal male and female rats were divided into control (C) and maternal separation (MS) groups (n = 20‐24 per group). The pups in the MS groups were placed in isolation cages for 240 minutes/d from postnatal days 2‐11. Vaginal opening (VO) in females and preputial separation (PS) in males (indicators of sexual maturation) were monitored, as was the estrous cycle in females. Thereafter, sexual behavior was monitored twice at 13 and 15 weeks of age. Results As for sexual maturation, the onset of PS occurred significantly earlier in the MS group than in the C group, whereas the onset of VO did not differ between the groups. The length of the estrous cycle did not differ between the groups. The frequencies of sexual behaviors did not differ between the groups in either sex. Conclusions In conclusion, early‐life psychological stress induced by MS advanced sexual maturation in male rats, whereas it did not affect sexual maturation in female rats. On the other hand, early‐life psychological stress might not affect sexual behavior in adulthood in either sex.
Databáze: Directory of Open Access Journals
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