Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility.

Autor: S T Kunitake, K J La Sala, J P Kane
Jazyk: angličtina
Rok vydání: 1985
Předmět:
Zdroj: Journal of Lipid Research, Vol 26, Iss 5, Pp 549-555 (1985)
Druh dokumentu: article
ISSN: 0022-2275
DOI: 10.1016/S0022-2275(20)34341-8
Popis: Among the apoA-I-containing lipoproteins isolated by selected-affinity immunosorption from human serum and plasma, we have identified a subpopulation which, unlike the bulk of high density lipoproteins, has pre-beta electrophoretic mobility. This pre-beta subpopulation can be observed directly in fresh plasma by immunoelectrophoresis. It contains phospholipid and free and esterified cholesterol, but protein constitutes 90% of its mass. Apolipoprotein A-I is the predominant apolipoprotein in this subpopulation; apolipoprotein A-II and the B lipoproteins are not detected. The protein moiety of this subpopulation exhibits markedly lower helicity than that of high density lipoproteins isolated by ultracentrifugation.
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