A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate

Autor: Anders Lindholm Sørensen, Klaus Kallenbach, Hans Carl Hasselbalch
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Leukemia Research Reports, Vol 6, Iss C, Pp 20-23 (2016)
Druh dokumentu: article
ISSN: 2213-0489
DOI: 10.1016/j.lrr.2016.06.004
Popis: We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.
Databáze: Directory of Open Access Journals