Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents

Autor:	Giulia Petroni, Lorenzo Galluzzi
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	4t1 cells immune checkpoint inhibitors mcf7 cells mpa/dmba-driven mammary carcinomas targeted anticancer agents ts/a cells Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 10, Iss 1 (2021)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2021.1889101
Popis:	Radiation therapy (RT) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors mediate poorly overlapping cytostatic and immunostimulatory effects, suggesting that combinatorial regimens may enable supra-additive tumor control. Our preclinical findings demonstrate that administration schedule stands out as a major determinant of efficacy when RT and CDK4/6 inhibitors are combined for breast cancer therapy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0089cac6adef4f789adc840385262058 Zobrazit plný text záznamu View record in DOAJ