Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

Autor: Kei Miyakawa, Mayuko Nishi, Michinaga Ogawa, Satoko Matsunaga, Masaya Sugiyama, Hironori Nishitsuji, Hirokazu Kimura, Makoto Ohnishi, Koichi Watashi, Kunitada Shimotohno, Takaji Wakita, Akihide Ryo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-28171-5
Popis: In human cells, invading pathogens trigger an innate immune response that helps prevent viral replication and spread. Here, the authors reveal a mechanism of innate immunity that selectively leads to the autophagic degradation of hepatitis B virus core protein.
Databáze: Directory of Open Access Journals