Sulfur-containing heterocyclic compounds with potential antidiabetic activity
| Autor: | E. A. Savateeva, V. V. Emelyanov, A. V. Musalnikova, L. P. Sidorova, N. E. Maksimova, N. N. Machulskaya, V. A. Chereshnev |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Chimica Techno Acta, Vol 1, Iss 3, Pp 83-86 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2409-5613 2411-1414 |
| DOI: | 10.15826/chimtech.2014.1.3.1161 |
| Popis: | The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|