Antiurolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Autor: Amany A. Sayed, Amel M. Soliman, Sohair R. Fahmy, Rasha Hosny
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Basic and Applied Zoology, Vol 84, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 2090-990X
DOI: 10.1186/s41936-023-00336-8
Popis: Abstract Background The present study assesses the role of polyherbal formula (LACTN) against sodium oxalate (NaOx)—stimulated urolithiasis prophylactic and curative. Forty-eight rats were separated into the following regimen’s groups: Groups I, II, III, and IV (prophylactic groups). Group I (control group) received saline as vehicle. Group II (urolithiatic group) received 70 mg NaOx / kg b.wt, i.p. Groups III and IV received LACTN and cystone prophylactic (500 and 750 mg/kg b.wt, respectively) from 1st day to 7th day of urolithiasis induction. Groups V, VI, VII, and VIII (curative groups): these were divided into the prophylactic regimes, but LACTN and cystone were administered from 7th day to 14th day of urolithiasis induction. Results Urolithiatic rats co-/post-treated with LACTN and cystone elevated the urinary volume significantly (P
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