| Autor: |
Beatriz Vera, Naiara Martínez-Vélez, Enric Xipell, Arlet Acanda de la Rocha, Ana Patiño-García, Javier Saez-Castresana, Marisol Gonzalez-Huarriz, Manel Cascallo, Ramón Alemany, Marta M Alonso |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 11, Iss 1, p e0147211 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0147211 |
| Popis: |
Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors. VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro. In vivo, in two different orthotopic glioma models, a single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free of disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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