| Autor: |
Thiago J. Borges, Naoka Murakami, Felipe D. Machado, Ayesha Murshid, Benjamin J. Lang, Rafael L. Lopes, Laura M. Bellan, Mayuko Uehara, Krist H. Antunes, Maria José Pérez-Saéz, Gabriel Birrane, Priscila Vianna, João Ismael B. Gonçalves, Rafael F. Zanin, Jamil Azzi, Reza Abdi, Satoshi Ishido, Jeoung-Sook Shin, Ana Paula D. Souza, Stuart K. Calderwood, Leonardo V. Riella, Cristina Bonorino |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-018-05572-z |
| Popis: |
Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on do-DCs by DnaK pre-treatment can decrease the priming of alloimmunity and prolong graft survival in mouse models. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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