Six-month retention and changes in quality of life and substance use from a low-threshold methadone maintenance therapy programme in Durban, South Africa

Autor: Andrew Scheibe, Shaun Shelly, Tara Gerardy, Zara von Homeyer, Andrea Schneider, Kalvanya Padayachee, Shalon Balaguru Naidoo, Klaas Mtshweni, Ayanda Matau, Harry Hausler, Monique Marks
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Addiction Science & Clinical Practice, Vol 15, Iss 1, Pp 1-11 (2020)
Druh dokumentu: article
ISSN: 1940-0640
DOI: 10.1186/s13722-020-00186-7
Popis: Abstract Background Emerging data points to a potential heroin use epidemic in South Africa. Despite this, access to methadone maintenance therapy and other evidence-based treatment options remains negligible. We aimed to assess retention, changes in substance use and quality of life after 6 months on methadone maintenance therapy provided through a low-threshold service in Durban, South Africa. Methods We enrolled a cohort of 54 people with an opioid use disorder into the study. We reviewed and described baseline socio-demographic characteristics. Baseline and 6-month substance use was assessed using the World Health Organization’s Alcohol Smoking and Substance Use Involvement Screening Test (ASSIST) and quality of life, using the SF-12. We compared changes at 6 months on methadone to baseline using the Wilcoxon signed rank test and paired-tests for the ASSIST and SF-12 scores, respectively. McNemar’s test was used for comparisons between paired results of categorical variables relating to injecting frequency. Results The majority of the participants were young, Black African males, with a history of drug use spanning over 10 years. Retention after 6 months was 81%. After 6 months, the median heroin ASSIST score decreased from 37 to 9 (p
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