Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy

Autor: Robin Jacob, MD, Paolo Strati, MD, Nicolas Palaskas, MD, Juan C. Lopez-Mattei, MD, Konstantinos Marmagkiolis, MD, L. Maximilian Buja, MD, Anita Deswal, MD, Cezar Iliescu, MD
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: JACC: Case Reports, Vol 2, Iss 13, Pp 2095-2100 (2020)
Druh dokumentu: article
ISSN: 2666-0849
DOI: 10.1016/j.jaccas.2020.07.033
Popis: A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.)
Databáze: Directory of Open Access Journals