Functional Brain Receptor Imaging with Positron Emission Tomography

Autor:	Simon M. Ametamey, Gerrit Westera, Pascale Gucker, Roland Schönbächler, Michael Honer, Jörg E. Spang, P. August Schubiger
Jazyk:	German<br />English<br />French
Rok vydání:	2000
Předmět:	Dopamine and serotonin transporters Ecstasy Epibatidine Pet Pharmaceutical chemistry Chemistry QD1-999
Zdroj:	CHIMIA, Vol 54, Iss 11 (2000)
Druh dokumentu:	article
ISSN:	0009-4293 2673-2424
Popis:	A new cocaine derivative for imaging the dopamine transporter has been developed. Measurements of radioligand binding of 11C-(+)-McN-5652 in vivo with PET suggests that ecstasy interacts directly with the serotonin reuptake sites and that a single oral dose of ecstasy (1.5 mg/kg) does not cause any changes in the serotonin transporter density in the human brain. Finally, a number of epibatidine derivatives have been developed as ligands to study the central nAChRs in vivo, however, toxicity studies prevented further clinical use.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0029adc6a705459990702b0b6d2efe9b Zobrazit plný text záznamu View record in DOAJ