Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders

Autor: Ya Chai, José R. Chimelis-Santiago, Kristy A. Bixler, Matthew Aalsma, Meichen Yu, Leslie A. Hulvershorn
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: NeuroImage: Clinical, Vol 32, Iss , Pp 102789- (2021)
Druh dokumentu: article
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2021.102789
Popis: Background: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fronto-subcortical connectivity in youth with attention-deficit/hyperactivity disorder (ADHD). Methods: The current study used functional magnetic resonance imaging (fMRI) to examine sex differences in resting-state seed-based FC, self-rated impulsivity, and their interactions in 11-12-year-old boys (n = 43) and girls (n = 43) with externalizing disorders. Generalized linear models controlling for pubertal development were used. Seeds were chosen in the ventral striatum, medial prefrontal cortex, middle frontal gyrus and amygdala. Results: Impulsivity scores were greater in boys than girls (p
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