Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity

Autor: Ningning Zhao, Fan Wu, Jieqi Peng, Youlan Zheng, Heshen Tian, Huajing Yang, Zhishan Deng, Zihui Wang, Haiqing Li, Xiang Wen, Shan Xiao, Peiyu Huang, Cuiqiong Dai, Lifei Lu, Kunning Zhou, Shengtang Chen, Yumin Zhou, Pixin Ran
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 1465-993X
DOI: 10.1186/s12931-022-02216-1
Popis: Abstract Background: Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV1) in the setting of preserved ratio. Little is known about the role of PRISm and its complex relation with small airway dysfunction (SAD) and lung volume. Therefore, we aimed to investigate the associations between PRISm and SAD and lung volume. Methods: We conducted a cross-sectional community-dwelling study in China. Demographic data, standard respiratory epidemiology questionnaire, spirometry, impulse oscillometry (IOS) and computed tomography (CT) data were collected. PRISm was defined as post-bronchodilator FEV1/FVC ≥ 0.70 and FEV1 0.07 kPa/L/s and LAA− 856>20%, respectively. Analysis of covariance and logistic regression were used to determine associations between PRISm and SAD and lung volume. We then repeated the analysis with a lower limit of normal definition of spirometry criteria and FVC definition of PRISm. Moreover, we also performed subgroup analyses in ever smoker, never smoker, subjects without airway reversibility or self-reported diagnosed asthma, and subjects with CT-measured total lung capacity ≥70% of predicted. Results: The final analysis included 1439 subjects. PRISm had higher odds and more severity in spirometry-defined SAD (pre-bronchodilator: odds ratio [OR]: 5.99, 95% confidence interval [95%CI]: 3.87–9.27, P
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