| Autor: |
C.E. Bekolo, S.A. Ndeso, C.P. Gougue, L.L. Moifo, N. Mangala, P. Tchendjou, E. Mboh, J. Ateudjieu, N. Tendongfor, D.S. Nsagha, G.E. Halle-Ekane, S.P. Choukem |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Dialogues in Health, Vol 2, Iss , Pp 100120- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2772-6533 |
| DOI: |
10.1016/j.dialog.2023.100120 |
| Popis: |
Background: Cameroon adopted and started implementing in 2016, the ‘universal test and treat’ (UTT) guidelines to fast-track progress towards the 95-95-95 ambitious targets to end the HIV epidemic. UTT has shown inconsistent results elsewhere and has not yet been assessed in Cameroon. We aimed to evaluate the effectiveness of this novel approach on the quality of care and health outcomes of people living with HIV (PLHIV). Methods: A retrospective cohort design was conducted at The Nkongsamba Regional Hospital, using routine clinical service delivery data to measure uptake levels of UTT and CD4 testing, and to compare the incidence of opportunistic infections (OI) between PLHIV initiated on ART based on the “Universal Test and Treat” strategy and those initiated on ART based on the standard deferred approach between 2002 and 2020. Kaplan Meier plots and log-rank tests were used to compare OI events between the pre-UTT and post-UTT eras. The Cox regression model was used to screen for factors independently associated with the risk of acquisition of OI. Results: The uptake of UTT ranged from 39.1% to 92.8% while baseline CD4 count testing reduced drastically from 89.4% to 0.4% between 2016 to 2020 respectively. The median delay in ART initiation declined significantly from 21 days (IQR: 9 – 113) in the pre-UTT era to the same day of diagnosis (IQR: 0 – 2) in the UTT era (p < 0.001). The incidence of all OI events reported was over five times higher during the UTT era than in the pre-UTT era [aHR = 5.55 (95% CI: 3.18 – 9.69), p < 0.001]. Conclusion: The UTT policy has been effectively rolled out and has contributed to improved access to rapid and immediate ART initiation, but a higher incidence of OIs was observed with a rollback of baseline CD4 testing. We advocate for a return to routine baseline CD4 measurement to identify PLHIV who should benefit from interventions to prevent OIs for optimal outcomes under the UTT approach. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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